November 2020, Beijing University Nuclear Physics and Nuclear Technology Country Key Laboratory Yang Gen Research Group and Quantitative Biological Center Luo Chunxiong Research Group issued on "A Novel Microfluidic Device Integrating Focus-Separation" in "Lab On A Chip" Speed Reduction Design and Trap Arrays for High-Throughput Capture Of Circulating Tumor Cells "Research papers realize fast and efficient and high purity from the blood from cancer patients (Lab CHIP 20: 4094-4105, 2020).
Overall schematic of chip
Cancer from happening to clinical findings often take 10 years, the fundamental pathway of cancer treatment is early discovery or effective treatment of metastatic tumors. Circulating Tumor Cells (CTC) refers to tumor cells from the in situ tumor to the circulatory system. As the CTC of the precise medical and liquid biopsy core target, it can be used not only for early screening prior to cancer metastasis, but also has extremely important in terms of clinical tumors, prognosis, specific drug screening, efficacy testing, treatment and recurrence monitoring. Clinical application value. However, since the number of CTC is extremely rare (about 1-100 / ml) in the blood, its efficient and high and accurate capture has always been a key obstacle to frontier scientific problems and clinical applications.
The Yang Genchi team has worked closely with Luo Chunxiong Research Group to propose a new design of a integrated microfluidic chip that will integrate streamlined speed-up structure and filter-based capture structure. (5-40 ml / h) achieve high efficiency (up to 94.8%) and high purity capture (4 Log leukocyte removal rate). The topic group also conducted clinical double-blind experiments with Jining Branch of Shandong Qilu Hospital. The CTC in 11 patients with lung cancer, breast cancer and liver cancer was double-blind. The detection rate was as high as 100%, of which CTC number was from 6- 117 / ml inequality, the average of 31 / ml, the median number of 25 / ml. Since the chip has a low cost, it is very suitable for large-scale clinical applications for large-scale clinical applications with low cost, high efficiency, high efficiency. The microfluidic chip is currently applied for a domestic patent and international patent.
Beijing University Nuclear Physics and Nuclear Technology Country Key Laboratory of PhD Spring Yang and Physics School 17 Master Xu Jian is the first author of this article, the state of the nuclear physics and nuclear technology National Key Laboratory of Yang Gen, Deputy Professor and Physics Professor Luo Chunxiong as a joint communication author of this article, and other participants also included Professor Wang Yugang, a state-of-key laboratory of nuclear physics and nuclear technology, academician, Ouyang, Department of Physics, Peking University, School of Physics, Han Jintao and Li Xiao. This work has received funding and support for the focus of the National Natural Science Foundation and Projects.
The Yanggen Research Group has continued to study the core scientific issues of cancer diagnosis and treatment. The basic biophysical process of FLASH ultra-high dose rate radiotherapy is involved based on laser pulse proton accelerator (Cancer Science 111: 467-476, 2020; cover), cell Environment (Biotechnic & Histochemistry 95: 605-612, 2020; Biomedical MicroDevices 22: 40-47, 2020) and intracellular chromatin structures (Science China Life Sciences 63: 825-834, 2020) during cancer metastasis Key role; invitation to summarize and look forward to CTC-based new POC cancer diagnostic strategies (Sensors 20, 6073; DOI: 10.3390 / S20216073, 2020); solid tumors (pancreatic cancer, mesopic carcinoma, ovarian cancer) Lung adenocarcinoma and triple-negative breast cancer have developed a specific therapeutic conjugate based on antibody and radioactive Alpha Nutrin AT-211 (Journal of Radiation Research 61: 684-690, 2020) and the positive electron-based CU- The specific imaging probe of 64 / I-124 (Molecular Pharmaceutics 17, 1875-1883, 2020, cover articles).
Editor: LQ, Reading full text, original title: Peking University research and development new microfluidic device, can be used for high-throughput capture of circulating tumor cells
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